Optical and material analysis of opacified hydrophilic intraocular lenses after explantation: a laboratory study
Identifieur interne : 000243 ( Main/Exploration ); précédent : 000242; suivant : 000244Optical and material analysis of opacified hydrophilic intraocular lenses after explantation: a laboratory study
Auteurs : Tamer Tandogan [Allemagne] ; Ramin Khoramnia [Allemagne] ; Chul Young Choi [Allemagne] ; Alexander Scheuerle [Allemagne] ; Martin Wenzel [Allemagne] ; Philipp Hugger [Allemagne] ; Gerd U. Auffarth [Allemagne]Source :
- BMC Ophthalmology [ 1471-2415 ] ; 2015.
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Abstract
The opacification of hydrophilic intraocular lenses (IOLs) is a very rare complication in terms of absolute numbers. We report on the analyses of opacified Euromaxx ALI313Y and ALI313 IOLs (Argonoptics, Germany) using light and scanning electron microscopy, X-ray spectroscopy and optical bench analysis.
Opacified Euromaxx ALI313Y and ALI313 IOLs were explanted after patients presented with a decrease in visual acuity. The explants were sent to our laboratory and examined using light and scanning electron microscopy. The composition of the deposits was analysed using X-ray spectroscopy. The optical quality of the intraocular lens (IOL) was assessed using the OptiSpheric IOL PRO optical bench (Trioptics GmbH Wedel, Germany). Modulation transfer function (MTF) was measured at all spatial frequencies and United States Air Force (USAF) 1951 resolution target pictures were documented.
Macroscopically, the entire optic was opacified in all IOLs. Light and scanning electron microscopy revealed numerous fine, granular, crystalline-like deposits, which were always distributed in a line parallel to the anterior and posterior surfaces of the IOLs. X-ray spectroscopy could prove the deposits consisted of Calcium and Phosphate. Measurements in the optical bench showed deterioration of MTF values at all spatial frequencies and the USAF target pictures demonstrated a significant reduction of brightness as well as resolution with the opacified IOLs.
The calcification of hydrophilic IOLs only occurs rarely. The exact chemical composition of the deposits can be assessed by means of X-ray spectroscopy. Optical quality analysis of the explanted Euromaxx ALI313Y and ALI313 IOLs showed significant reduction of MTF values, which was confirmed by USAF target pictures.
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DOI: 10.1186/s12886-015-0149-1
PubMed: 26606985
PubMed Central: 4659174
Affiliations:
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Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>David J Apple International Laboratory for Ocular Pathology and International Vision Correction Research Centre (IVCRC), Department of Ophthalmology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Khoramnia, Ramin" sort="Khoramnia, Ramin" uniqKey="Khoramnia R" first="Ramin" last="Khoramnia">Ramin Khoramnia</name><affiliation wicri:level="3"><nlm:aff id="Aff1">David J Apple International Laboratory for Ocular Pathology and International Vision Correction Research Centre (IVCRC), Department of Ophthalmology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>David J Apple International Laboratory for Ocular Pathology and International Vision Correction Research Centre (IVCRC), Department of Ophthalmology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Choi, Chul Young" sort="Choi, Chul Young" uniqKey="Choi C" first="Chul Young" last="Choi">Chul Young Choi</name><affiliation wicri:level="3"><nlm:aff id="Aff1">David J Apple International Laboratory for Ocular Pathology and International Vision Correction Research Centre (IVCRC), Department of Ophthalmology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>David J Apple International Laboratory for Ocular Pathology and International Vision Correction Research Centre (IVCRC), Department of Ophthalmology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation><affiliation><nlm:aff id="Aff4">Department of Ophthalmology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Pyeong-dong, Jongno-gu, Seoul South Korea</nlm:aff><wicri:noCountry code="subfield">Seoul South Korea</wicri:noCountry></affiliation></author><author><name sortKey="Scheuerle, Alexander" sort="Scheuerle, Alexander" uniqKey="Scheuerle A" first="Alexander" last="Scheuerle">Alexander Scheuerle</name><affiliation wicri:level="3"><nlm:aff id="Aff1">David J Apple International Laboratory for Ocular Pathology and International Vision Correction Research Centre (IVCRC), Department of Ophthalmology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>David J Apple International Laboratory for Ocular Pathology and International Vision Correction Research Centre (IVCRC), Department of Ophthalmology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Wenzel, Martin" sort="Wenzel, Martin" uniqKey="Wenzel M" first="Martin" last="Wenzel">Martin Wenzel</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Eye Clinic Petrisberg, Trier, Germany, Max-Planck-Straße 16, 54296 Trier, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Eye Clinic Petrisberg, Trier, Germany, Max-Planck-Straße 16, 54296 Trier</wicri:regionArea><wicri:noRegion>54296 Trier</wicri:noRegion><wicri:noRegion>54296 Trier</wicri:noRegion><wicri:noRegion>54296 Trier</wicri:noRegion></affiliation></author><author><name sortKey="Hugger, Philipp" sort="Hugger, Philipp" uniqKey="Hugger P" first="Philipp" last="Hugger">Philipp Hugger</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Eye Clinic Esslingen, Esslingen, Germany, Augen-Praxis-Klinik-Esslingen Adlerstraße 6, 73728 Esslingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Eye Clinic Esslingen, Esslingen, Germany, Augen-Praxis-Klinik-Esslingen Adlerstraße 6, 73728 Esslingen</wicri:regionArea><wicri:noRegion>73728 Esslingen</wicri:noRegion><wicri:noRegion>73728 Esslingen</wicri:noRegion><wicri:noRegion>73728 Esslingen</wicri:noRegion></affiliation></author><author><name sortKey="Auffarth, Gerd U" sort="Auffarth, Gerd U" uniqKey="Auffarth G" first="Gerd U." last="Auffarth">Gerd U. Auffarth</name><affiliation wicri:level="3"><nlm:aff id="Aff1">David J Apple International Laboratory for Ocular Pathology and International Vision Correction Research Centre (IVCRC), Department of Ophthalmology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>David J Apple International Laboratory for Ocular Pathology and International Vision Correction Research Centre (IVCRC), Department of Ophthalmology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author></analytic><series><title level="j">BMC Ophthalmology</title><idno type="eISSN">1471-2415</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Calcinosis</term><term>Calcium (analysis)</term><term>Device Removal</term><term>Equipment Failure Analysis</term><term>Humans</term><term>Lens Implantation, Intraocular</term><term>Lenses, Intraocular</term><term>Microscopy, Electron, Scanning</term><term>Phacoemulsification</term><term>Phosphates (analysis)</term><term>Prosthesis Failure</term><term>Spectrometry, X-Ray Emission</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Calcium</term><term>Phosphates</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Calcinosis</term><term>Device Removal</term><term>Equipment Failure Analysis</term><term>Humans</term><term>Lens Implantation, Intraocular</term><term>Lenses, Intraocular</term><term>Microscopy, Electron, Scanning</term><term>Phacoemulsification</term><term>Prosthesis Failure</term><term>Spectrometry, X-Ray Emission</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>The opacification of hydrophilic intraocular lenses (IOLs) is a very rare complication in terms of absolute numbers. We report on the analyses of opacified Euromaxx ALI313Y and ALI313 IOLs (Argonoptics, Germany) using light and scanning electron microscopy, X-ray spectroscopy and optical bench analysis.</p></sec><sec><title>Methods</title><p>Opacified Euromaxx ALI313Y and ALI313 IOLs were explanted after patients presented with a decrease in visual acuity. The explants were sent to our laboratory and examined using light and scanning electron microscopy. The composition of the deposits was analysed using X-ray spectroscopy. The optical quality of the intraocular lens (IOL) was assessed using the OptiSpheric IOL PRO optical bench (Trioptics GmbH Wedel, Germany). Modulation transfer function (MTF) was measured at all spatial frequencies and United States Air Force (USAF) 1951 resolution target pictures were documented.</p></sec><sec><title>Results</title><p>Macroscopically, the entire optic was opacified in all IOLs. Light and scanning electron microscopy revealed numerous fine, granular, crystalline-like deposits, which were always distributed in a line parallel to the anterior and posterior surfaces of the IOLs. X-ray spectroscopy could prove the deposits consisted of Calcium and Phosphate. Measurements in the optical bench showed deterioration of MTF values at all spatial frequencies and the USAF target pictures demonstrated a significant reduction of brightness as well as resolution with the opacified IOLs.</p></sec><sec><title>Conclusions</title><p>The calcification of hydrophilic IOLs only occurs rarely. The exact chemical composition of the deposits can be assessed by means of X-ray spectroscopy. Optical quality analysis of the explanted Euromaxx ALI313Y and ALI313 IOLs showed significant reduction of MTF values, which was confirmed by USAF target pictures.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Khoramnia, R" uniqKey="Khoramnia R">R Khoramnia</name></author><author><name sortKey="Salgado, Jp" uniqKey="Salgado J">JP Salgado</name></author><author><name sortKey="Auffarth, Gu" uniqKey="Auffarth G">GU Auffarth</name></author><author><name sortKey="Schmidt, S" uniqKey="Schmidt S">S Schmidt</name></author><author><name sortKey="Wegner, A" uniqKey="Wegner A">A Wegner</name></author><author><name sortKey="Kobuch, Ka" uniqKey="Kobuch K">KA Kobuch</name></author><author><name sortKey="Winkler Von Mohrenfels, C" uniqKey="Winkler Von Mohrenfels C">C Winkler von Mohrenfels</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fung, Ss" uniqKey="Fung S">SS Fung</name></author><author><name sortKey="Sykakis, E" uniqKey="Sykakis E">E Sykakis</name></author><author><name sortKey="Islam, Nm" uniqKey="Islam N">NM Islam</name></author><author><name sortKey="Zambarakji, Hj" uniqKey="Zambarakji H">HJ Zambarakji</name></author><author><name sortKey="Khoramnia, R" uniqKey="Khoramnia R">R Khoramnia</name></author><author><name sortKey="Auffarth, Gu" uniqKey="Auffarth G">GU Auffarth</name></author><author><name sortKey="Parmar, Dn" uniqKey="Parmar D">DN Parmar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schmidinger, G" uniqKey="Schmidinger G">G Schmidinger</name></author><author><name sortKey="Pemp, B" uniqKey="Pemp B">B Pemp</name></author><author><name sortKey="Werner, L" uniqKey="Werner L">L Werner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Izak, Am" uniqKey="Izak A">AM Izak</name></author><author><name sortKey="Werner, L" uniqKey="Werner L">L Werner</name></author><author><name sortKey="Pandey, Sk" uniqKey="Pandey S">SK Pandey</name></author><author><name sortKey="Apple, Dj" uniqKey="Apple D">DJ Apple</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Werner, L" uniqKey="Werner L">L Werner</name></author><author><name sortKey="Hunter, B" uniqKey="Hunter B">B Hunter</name></author><author><name sortKey="Stevens, S" uniqKey="Stevens S">S Stevens</name></author><author><name sortKey="Chew, Jj" uniqKey="Chew J">JJ Chew</name></author><author><name sortKey="Mamalis, N" uniqKey="Mamalis N">N Mamalis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dagres, E" uniqKey="Dagres E">E Dagres</name></author><author><name sortKey="Khan, Ma" uniqKey="Khan M">MA Khan</name></author><author><name sortKey="Kyle, Gm" uniqKey="Kyle G">GM Kyle</name></author><author><name sortKey="Clark, D" uniqKey="Clark D">D Clark</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Madrid Costa, D" uniqKey="Madrid 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Fernandez-Hortelano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dhaliwal, Dk" uniqKey="Dhaliwal D">DK Dhaliwal</name></author><author><name sortKey="Mamalis, N" uniqKey="Mamalis N">N Mamalis</name></author><author><name sortKey="Olson, Rj" uniqKey="Olson R">RJ Olson</name></author><author><name sortKey="Crandall, As" uniqKey="Crandall A">AS Crandall</name></author><author><name sortKey="Zimmerman, P" uniqKey="Zimmerman P">P Zimmerman</name></author><author><name sortKey="Alldredge, Oc" uniqKey="Alldredge O">OC Alldredge</name></author><author><name sortKey="Durcan, Fj" uniqKey="Durcan F">FJ Durcan</name></author><author><name sortKey="Omar, O" uniqKey="Omar O">O Omar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Allers, A" uniqKey="Allers A">A Allers</name></author><author><name sortKey="Baumeister, M" uniqKey="Baumeister M">M Baumeister</name></author><author><name sortKey="Steinkamp, Gw" uniqKey="Steinkamp G">GW Steinkamp</name></author><author><name sortKey="Ohrloff, C" uniqKey="Ohrloff C">C Ohrloff</name></author><author><name sortKey="Kohnen, T" uniqKey="Kohnen T">T Kohnen</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bade-Wurtemberg</li><li>District de Karlsruhe</li></region><settlement><li>Heidelberg</li></settlement></list><tree><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Tandogan, Tamer" sort="Tandogan, Tamer" uniqKey="Tandogan T" first="Tamer" last="Tandogan">Tamer Tandogan</name></region><name sortKey="Auffarth, Gerd U" sort="Auffarth, Gerd U" uniqKey="Auffarth G" first="Gerd U." last="Auffarth">Gerd U. Auffarth</name><name sortKey="Choi, Chul Young" sort="Choi, Chul Young" uniqKey="Choi C" first="Chul Young" last="Choi">Chul Young Choi</name><name sortKey="Hugger, Philipp" sort="Hugger, Philipp" uniqKey="Hugger P" first="Philipp" last="Hugger">Philipp Hugger</name><name sortKey="Khoramnia, Ramin" sort="Khoramnia, Ramin" uniqKey="Khoramnia R" first="Ramin" last="Khoramnia">Ramin Khoramnia</name><name sortKey="Scheuerle, Alexander" sort="Scheuerle, Alexander" uniqKey="Scheuerle A" first="Alexander" last="Scheuerle">Alexander Scheuerle</name><name sortKey="Wenzel, Martin" sort="Wenzel, Martin" uniqKey="Wenzel M" first="Martin" last="Wenzel">Martin Wenzel</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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